Soulier S M, Page J C, Larsen L C, Grose B C
Upjohn Company: Pharmacia & Upjohn, Kalamazoo, MI, USA.
J Foot Ankle Surg. 1997 Nov-Dec;36(6):414-7; discussion 466. doi: 10.1016/s1067-2516(97)80091-9.
Eighty-three patients scheduled for outpatient surgery were enrolled in this double-blind, randomized trial designed to compare the safety and efficacy of single and multiple doses of flurbiprofen 50 mg. and acetaminophen 300 mg. plus codeine phosphate 30 mg. During the multiple dose segment, statistically significant differences were observed during the first 24 hour postoperative period regarding relief of pain and pain intensity. Flurbiprofen provided greater relief of pain than the acetaminophen with codeine phosphate combination. This study supports the use of flurbiprofen as a suitable alternative to acetaminophen plus codeine phosphate in the treatment of postoperative pain following foot surgery.
83名计划接受门诊手术的患者参与了这项双盲随机试验,该试验旨在比较单次和多次服用50毫克氟比洛芬、300毫克对乙酰氨基酚加30毫克磷酸可待因的安全性和有效性。在多剂量阶段,术后头24小时内在疼痛缓解和疼痛强度方面观察到了统计学上的显著差异。氟比洛芬比乙酰氨基酚与磷酸可待因组合能更好地缓解疼痛。本研究支持将氟比洛芬作为足部手术后治疗术后疼痛时替代乙酰氨基酚加磷酸可待因的合适药物。