Alter M, Cendrowski W
Neurology. 1976 Mar;26(3):201-4. doi: 10.1212/wnl.26.3.201.
There is evidence that some event in childhood may determine risk of multiple sclerosis: Elevated titers to measles and other childhood infections suggest a childhood infection. Therefore, childhood infections reported by 30 patients with multiple sclerosis and matched controls were compared. Patients reported a childhood infection between 5 and 9 years (not simply exposure to an infection) more often than controls. The mean age of measles peaked somewhat later (age 7) in patients than in controls (age 4); this differnce approached statistical significance (p less than 0.1). Evidence that host response to measles is age-dependent was reviewed. It was proposed that age of measles (rather than the fact of injection) may influence the risk of developing multiple sclerosis.
针对麻疹和其他儿童期感染的滴度升高表明曾有过儿童期感染。因此，对30例多发性硬化症患者及其匹配的对照组报告的儿童期感染情况进行了比较。患者报告在5至9岁之间曾患过儿童期感染（而非仅仅是接触过感染源）的情况比对照组更为常见。麻疹发病的平均年龄在患者中（7岁）比对照组（4岁）稍晚达到峰值；这种差异接近统计学显著性（p小于0.1）。对宿主对麻疹的反应具有年龄依赖性的证据进行了综述。有人提出麻疹发病的年龄（而非感染这一事实）可能会影响患多发性硬化症的风险。
