Haile R W, Visscher B R, Detels R, Valdiviezo N L, Sever J L, Madden D L
J Neurol. 1981;224(4):235-42. doi: 10.1007/BF00313286.
Recently published studies of formal linkage analyses strongly suggest that a multiple sclerosis susceptibility (MSS) gene is linked to the HLA region of the sixth chromosome. The objective of this analysis was to investigate whether or not the gene has any demonstrable relationship to the immune status with regard to measles within members of multiple-case MS families. Family members were HLA-typed, and levels of antibodies to measles were determined using the hemagglutination inhibition assay. Since a specific, HLA-defined haplotype within each family is presumably a marker for the MSS gene, family members were characterized as either carrying [(+) controls] or not carrying [(-) controls] the MSS gene by the presence of this specific haplotype. Twenty families were entered into the analyses. Results revealed that the mean titer to measles was not different between (+) and (-) controls, and that MS cases had significantly higher titers than both control groups combined.
最近发表的关于正式连锁分析的研究强烈表明，多发性硬化易感性（MSS）基因与第六条染色体的HLA区域相关联。本分析的目的是研究该基因在多病例MS家族成员中与麻疹免疫状态是否存在任何可证明的关系。对家庭成员进行了HLA分型，并使用血凝抑制试验测定了麻疹抗体水平。由于每个家族中特定的、由HLA定义的单倍型可能是MSS基因的标记，因此通过该特定单倍型的存在将家庭成员表征为携带[（+）对照]或不携带[（-）对照]MSS基因。二十个家族进入了分析。结果显示，（+）和（-）对照之间的麻疹平均滴度没有差异，并且MS病例的滴度显著高于两个对照组的总和。
