Zañartu J, Aguilera E, Muñoz G, Peliowsky H
Obstet Gynecol. 1976 Feb;47(2):174-6.
A prospective study was made on the duration of lactation in 406 mothers injected postpartum for contraception with medroxyprogesterone acetate (DMPA), 150 or 250-300 mg, IM, at 3- or 6-month intervals. Breast feedings up to 2 per day were recorded, and findings compared with those from 173 nontreated controls. Eighty percent of the DMPA group were nursing successfully at the sixth month and 42% at the 12th month postpartum. These figures are significant and compare favorably with the control group. No advantage was found in the administration of DMPA earlier than the second or third month after delivery. Amenorrhea persisted during lactation. No pathologic breast conditions were observed. The eventual mechanism of DMPA in galactopoiesis has yet to be clarified.
对406名产后注射醋酸甲羟孕酮（DMPA）用于避孕的母亲进行了一项前瞻性研究，注射剂量为150或250 - 300毫克，肌肉注射，间隔3或6个月。记录每日最多2次的母乳喂养情况，并将结果与173名未接受治疗的对照组进行比较。DMPA组80%的母亲在产后第6个月成功进行母乳喂养，42%在第12个月成功进行母乳喂养。这些数据具有显著性，与对照组相比情况良好。未发现产后早于第2或第3个月注射DMPA有任何优势。哺乳期闭经持续存在。未观察到病理性乳腺疾病。DMPA在泌乳过程中的最终作用机制尚待阐明。
