Ben-Ishay D, Dikstein S, Shalita B
Pflugers Arch. 1976 Jan 30;361(2):153-7. doi: 10.1007/BF00583459.
Salt consumption was compared in two strains of rats, selected for their disparate proneness (strain "H") or resistance (strain "N") to Doca-salt hypertension. NaCl intake was similar in "H" and "N" rats prior to an following administration of Doca, while their respective blood pressures at the end of this experiment was 178 +/- 5mm Hg vs. 134 +/- 3 mm Hg. Thus, disparate responses of the blood pressure to Doca in the two strains cannot be ascribed to differences in salt intake. In another study, salt preference was tested in "H" and "N" rats by two-bottle self-selecting technique. Before Doca, saline preference in "H" rats averaged 60.3 +/- 5.8% of total daily fluid consumption, vs 18 +/- 4.2% in "N" rats. Following Doca treatment for 3 weeks the respective values were 96 +/- 1.7% vs 67 +/- 6.6%. Thus Doca treatment enhanced salt appetite in both strains, but salt preference remained significantly higher in the "H" rats. The increased susceptibility to hypertension and enhanced salt appetite in the "H" rat, corroborates similar reports in the Okamoto "SH" rat. In the Brookhaven "S" rat, however, susceptibility to hypertension is associated with salt avoidance. The conflicting data do not support a unified concept of a genetically determined link between salt appetite and proneness to hypertension.
对两种品系的大鼠的食盐消耗量进行了比较，这两种品系是根据它们对去氧皮质酮-盐性高血压的不同易感性（“H”品系）或抗性（“N”品系）挑选出来的。在给予去氧皮质酮之前和之后，“H”和“N”大鼠的氯化钠摄入量相似，而在该实验结束时它们各自的血压分别为178±5毫米汞柱和134±3毫米汞柱。因此，两个品系对去氧皮质酮的血压反应不同不能归因于盐摄入量的差异。在另一项研究中，通过双瓶自选技术测试了“H”和“N”大鼠的盐偏好。在给予去氧皮质酮之前，“H”大鼠对盐水的偏好平均占每日总液体消耗量的60.3±5.8%，而“N”大鼠为18±4.2%。去氧皮质酮治疗3周后，相应的值分别为96±1.7%和67±6.6%。因此，去氧皮质酮治疗增强了两个品系的盐食欲，但“H”大鼠的盐偏好仍然显著更高。“H”大鼠对高血压易感性增加和盐食欲增强，这与冈本“SH”大鼠的类似报道一致。然而，在布鲁克海文“S”大鼠中，高血压易感性与避盐有关。这些相互矛盾的数据不支持盐食欲与高血压易感性之间存在基因决定联系的统一概念。
