Variend S, O'Neill D, Arnold P
Department of Histopathology, Sheffield Children's Hospital, England.
Arch Pathol Lab Med. 1997 Dec;121(12):1272-6.
To determine whether cytomegaloviral (CMV) parotitis reflects a disseminated disease that increases vulnerability to unexpected death.
Necropsy-based cross-sectional study comparing incidences of brain stem microglial nodules and visceral lymphocytic infiltrates in patients with and without CMV parotitis.
One hundred twelve infants and young children comprising a study group of 40 individuals with CMV parotitis (including 32 whose deaths remained unexplained) and two comparison groups comprising 40 explained and 32 unexplained deaths.
Incidence and variation with age of brain stem microglial nodules and lymphocytic infiltrates in liver and kidneys.
Brain stem microglial nodules and lymphocytic infiltrates in liver and kidneys are strongly associated with CMV parotitis; their incidence diminishes with increasing age.
Disseminated disease frequently accompanies CMV parotitis in infants. The resolution of brain stem microglial nodules precedes that of parotitis. Active and previous brain stem involvement may increase vulnerability to unexpected death.
确定巨细胞病毒性（CMV）腮腺炎是否反映了一种播散性疾病，该疾病会增加意外死亡的易感性。
基于尸检的横断面研究，比较有和没有CMV腮腺炎患者的脑干小胶质结节和内脏淋巴细胞浸润的发生率。
112名婴幼儿，包括一个由40名患有CMV腮腺炎的个体组成的研究组（其中32例死亡原因不明），以及两个对照组，分别由40例死因明确和32例死因不明的死亡病例组成。
脑干小胶质结节以及肝脏和肾脏中淋巴细胞浸润的发生率及其随年龄的变化。
脑干小胶质结节以及肝脏和肾脏中的淋巴细胞浸润与CMV腮腺炎密切相关；其发生率随年龄增长而降低。
播散性疾病在婴儿CMV腮腺炎中经常伴随出现。脑干小胶质结节的消退先于腮腺炎。既往和当前的脑干受累可能会增加意外死亡的易感性。
