Tepsumethanon V, Lumlertdacha B, Mitmoonpitak C, Fagen R, Wilde H
Queen Saovabha Memorial Institute, Thai Red Cross Society (World Health Organization Collaborating Center for Research on Rabies Pathogenesis and Prevention), Chulalongkorn University, Bangkok, Thailand.
Clin Infect Dis. 1997 Dec;25(6):1459-61. doi: 10.1086/516151.
A prospective study of 8,987 canine, feline, human, and other mammalian brains (and one avian brain) was undertaken. The brains were analyzed for rabies antigens; two samples were obtained from each brainstem, and one sample was obtained from each hippocampus. The samples were stained with rabies conjugate and examined by use of fluorescence microscopy. There were no false-negative results. We conclude, therefore, that postexposure rabies treatment is not requisite in all cases, provided that the fluorescent antibody test is performed without delay in a laboratory experienced with the procedure and microscopy results are fluorescent negative.
对8987个犬类、猫科、人类及其他哺乳动物的大脑（以及一个禽类大脑）进行了一项前瞻性研究。对这些大脑进行狂犬病抗原分析；从每个脑干获取两个样本，从每个海马体获取一个样本。样本用狂犬病结合物染色，并使用荧光显微镜进行检查。没有假阴性结果。因此，我们得出结论，只要在有该检测经验的实验室及时进行荧光抗体检测且显微镜检查结果为荧光阴性，那么暴露后狂犬病治疗并非在所有情况下都是必需的。
