Schnedl W J, Leitner G, Lipp R W
Aus der Medizinischen Universitätsklinik.
Wien Med Wochenschr. 1997;147(15):359-61.
The target of therapy in patients with diabetes mellitus is preventing the development of late complications due to nearly normal blood glucose values. For the diagnosis and control of therapy in routine management of diabetes mellitus, determination of glycated haemoglobin (HbA1c) and fructosamine in addition to blood glucose values are of equal importance. This report stresses the clinical use, standard-determination methods and interpretation of glycated protein values. The problems of haemoglobin variants detected in Austria interfering with determination of HbA1c using the high performance liquid chromatography method and the suggestions of the American Diabetes Association for using glycated haemoglobin and fructosamine are discussed as well.
糖尿病患者的治疗目标是通过使血糖值接近正常来预防晚期并发症的发生。在糖尿病的常规管理中，除血糖值外，糖化血红蛋白（HbA1c）和果糖胺的测定对于诊断和治疗控制同样重要。本报告强调糖化蛋白值的临床应用、标准测定方法及解读。文中还讨论了在奥地利检测到的血红蛋白变异体干扰高效液相色谱法测定HbA1c的问题，以及美国糖尿病协会关于使用糖化血红蛋白和果糖胺的建议。
