John W G, Scott K W, Hawcroft D M
Department of Clinical Chemistry, New Cross Hospital, Wolverhampton.
J Clin Pathol. 1988 Apr;41(4):415-8. doi: 10.1136/jcp.41.4.415.
Glycated haemoglobin and glycated protein (fructosamine) and blood glucose concentrations were measured in blood samples collected from 75 patients at necropsy. Estimation of blood glucose was a poor indicator of glycaemia before death. Measurement of glycated haemoglobin by affinity chromatography distinguished non-diabetic patients from diabetic patients. The distinction was not as clear cut when HbA1 was estimated using electroendosmosis. Seven patients, who at necropsy had no known history of diabetes, had glycated haemoglobin concentrations in the diabetic range. Two of these patients were found to be diabetic, and diabetes had been suspected at some time in another three patients. It is concluded that measurement of glycated haemoglobin or HbA1, in necropsy specimens is a valuable tool for assessing glycaemic control in known diabetic patients, and may be useful in diagnosing previously unsuspected diabetes.
对75例尸检患者采集的血样进行了糖化血红蛋白、糖化蛋白（果糖胺）和血糖浓度的检测。血糖估计值并不能很好地反映死亡前的血糖水平。通过亲和层析法测定糖化血红蛋白可区分非糖尿病患者和糖尿病患者。用电渗法估计糖化血红蛋白A1（HbA1）时，这种区分并不那么明显。7例尸检时无糖尿病病史的患者，其糖化血红蛋白浓度处于糖尿病范围。其中2例患者被发现患有糖尿病，另外3例患者曾在某个时候被怀疑患有糖尿病。结论是，对尸检标本进行糖化血红蛋白或HbA1检测是评估已知糖尿病患者血糖控制情况的有价值工具，并且可能有助于诊断之前未被怀疑的糖尿病。
