Pidémskiĭ E L, Mardanova L G
Farmakol Toksikol. 1976 Jan-Feb;39(1):114-9.
The effects of prednisolone (1 mg/kg), nicophezone (10 mg/kg), phenylbutazone 30 mg/kg) and antradion (60 mg/kg) on choleresis and bilirubin passage with bile was studied in intact and CCl4-poisoned rats (by using hemolyzed blood loads). Intravenous administration of hemolyzed blood to intact animals was shown to be attended by an increased excretion of bilirubin with the bile. When superimposed upon the CCl4 poisoning--the excretion of bilirubin diminishes. The study compounds stimulated the passage of bilirubin with the bile following introduction of hemolyzed blood both in intact animals and in the ones with the CCl4-damaged liver. The data thus made available are used in interpreting the mechanism underlying the hypobilirubinemic effect of the compounds.
在完整大鼠和四氯化碳中毒大鼠（通过使用溶血血液负荷）中，研究了泼尼松龙（1毫克/千克）、尼可佐腙（10毫克/千克）、保泰松（30毫克/千克）和安曲安（60毫克/千克）对胆汁分泌和胆红素随胆汁排出的影响。向完整动物静脉注射溶血血液后，胆汁中胆红素的排泄增加。当叠加在四氯化碳中毒之上时，胆红素的排泄减少。所研究的化合物在完整动物和四氯化碳损伤肝脏的动物中，在引入溶血血液后均刺激了胆红素随胆汁排出。由此获得的数据用于解释这些化合物低胆红素血症作用的潜在机制。
