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一种用于展示基因组筛查连锁结果的图形方法。

A graphical approach for presenting linkage results from a genomic screen.

作者信息

Pugh E W, Mandal D M, Wilson A F

机构信息

Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans, USA.

出版信息

Genet Epidemiol. 1995;12(6):807-12. doi: 10.1002/gepi.1370120646.

Abstract

Initially, a sib-pair linkage analysis was performed between the marker loci and six untransformed variables. Results from several variations of this initial analysis were compared using a graphical approach (P-plots) to simplify presentation. When results were compared to the generating model, most of the aspects of the generating model were recovered, although we did not find evidence of the polygenic component shared by Q2 and Q3, or evidence of linkage between MG4 and Q4 at the 0.01 level.

摘要

最初,在标记位点与六个未转换变量之间进行了同胞对连锁分析。使用一种图形方法(P图)比较了该初始分析的几种变体的结果,以简化呈现。当将结果与生成模型进行比较时,生成模型的大多数方面都得以恢复,尽管我们没有找到Q2和Q3共享的多基因成分的证据,也没有找到在0.01水平上MG4与Q4之间连锁的证据。

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