Gu C, Todorov A A, Rao D C
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genet Epidemiol. 1997;14(6):791-6. doi: 10.1002/(SICI)1098-2272(1997)14:6<791::AID-GEPI38>3.0.CO;2-J.
We applied extreme sib-pair methods in two ways to the GAW10 Problem 2A data sets to detect susceptible quantitative trait loci using extremely discordant sib pairs only, and combining them with the available extremely concordant sib pairs as suggested by the authors elsewhere. Ten successive original replicates were combined into one sampling pool so as to get the necessary number of extreme sib pairs. A total of 100 replicates were used to produce 10 such data sets for both initial detection and confirmations. Strong signals were found with markers D5G15 for Q1, D8G27-28 for Q4, and D9G7-9 for Q5.
我们以两种方式将极端同胞对方法应用于GAW10问题2A数据集，仅使用极端不一致的同胞对来检测易感数量性状基因座，并按照作者在其他地方的建议，将它们与可用的极端一致同胞对相结合。将连续的10个原始重复样本合并到一个采样池中，以获得必要数量的极端同胞对。总共使用100个重复样本生成10个这样的数据集用于初始检测和验证。在标记D5G15处发现了与Q1相关的强信号，在D8G27 - 28处发现了与Q4相关的强信号，在D9G7 - 9处发现了与Q5相关的强信号。
