Meunier F, Philippi A, Martinez M, Demenais F
INSERM U. 358, Hôpital Saint-Louis, Paris, France.
Genet Epidemiol. 1997;14(6):1107-11. doi: 10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K.
We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) information appears robust. Missing parental marker data leads to a decrease of type I errors in all cases.
我们比较了针对多个患病同胞对（ASP）的检验在多个患病同胞家系中的稳健性。形成所有可能的同胞对只会使I类错误略有增加，而最常用的加权程序会降低检验效率。另一种考虑了加权全同胞相同等位基因（IBD）信息方差减少的加权程序似乎很稳健。在所有情况下，缺失亲代标记数据都会导致I类错误减少。
