Dina C, Buzzi J C, Demenais F, Martinez M
CNRS EP10, Lille, France.
Genet Epidemiol. 1997;14(6):1073-8. doi: 10.1002/(SICI)1098-2272(1997)14:6<1073::AID-GEPI85>3.0.CO;2-E.
We compare two simulation procedures used to determine empirical distributions of three affected sib-pair test-statistics in family samples with missing parental marker information. P1 and P2 procedures differ according to whether affected sibs' genotypes are ignored (P1) or accounted for (P2) to generate the unknown parental genotypes. Overall, our results show that P2 procedure performs better than P1, particularly when marker heterozygosity is high (H = 75%) or when marker data from unaffected siblings are available with low marker heterozygosity (H = 50%). These results are similar for all affected sib-pair tests.
我们比较了两种模拟程序，用于确定在缺少亲本标记信息的家系样本中三种患病同胞对检验统计量的经验分布。P1和P2程序的不同之处在于，生成未知亲本基因型时，是否忽略（P1）或考虑（P2）患病同胞的基因型。总体而言，我们的结果表明，P2程序比P1表现更好，特别是当标记杂合度高（H = 75%）时，或者当未患病同胞的标记数据可用且标记杂合度低（H = 50%）时。所有患病同胞对检验的这些结果都是相似的。
