阴茎皮肤和口腔黏膜醋酸白病变中EB病毒DNA和人乳头瘤病毒DNA的检测

Demonstration of Epstein-Barr virus DNA and human papillomavirus DNA in acetowhite lesions of the penile skin and the oral mucosa.

作者信息

Voog E, Ricksten A, Olofsson S, Ternesten A, Ryd W, Kjellström C, Forslund O, Löwhagen G B

机构信息

Department of Dermatology and Venereology, Sahlgrenska University Hospital, Göteborg, Sweden.

出版信息

Int J STD AIDS. 1997 Dec;8(12):772-5. doi: 10.1258/0956462971919255.

DOI:10.1258/0956462971919255

PMID:9433952

Abstract

Oral hairy leukoplakia (OHL), thought to be caused by Epstein-Barr virus (EBV), shows similar histological and clinical features to human papillomavirus (HPV)-related acetowhite lesions of the vulva. We thus aimed to investigate the role of both HPV and EBV in men with acetowhite lesions of the penis. HPV but not EBV was significantly associated with penile acetowhite lesions showing koilocytosis compared with normal penile skin (12/20 versus 5/20, P < 0.02). HPV (5/20) and EBV (6/20) was detected in oral mucosa of some of these individuals. These results confirm an aetiological association between HPV and acetowhite penile lesions showing koilocytosis. HPV and EBV carriage in the oral mucosa is relatively common in young sexually active men.

摘要

口腔毛状白斑（OHL）被认为是由爱泼斯坦-巴尔病毒（EBV）引起的，其组织学和临床特征与人类乳头瘤病毒（HPV）相关的外阴醋酸白病变相似。因此，我们旨在研究HPV和EBV在患有阴茎醋酸白病变的男性中的作用。与正常阴茎皮肤相比，HPV而非EBV与显示挖空细胞的阴茎醋酸白病变显著相关（12/20对5/20，P<0.02）。在其中一些个体的口腔黏膜中检测到了HPV（5/20）和EBV（6/20）。这些结果证实了HPV与显示挖空细胞的阴茎醋酸白病变之间的病因学关联。在年轻的性活跃男性中，口腔黏膜中HPV和EBV携带相对常见。