Morykwas M J, Argenta L C
Department of Plastic and Reconstructive Surgery, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1075, USA.
J South Orthop Assoc. 1997 Winter;6(4):279-88.
The rapidly aging population and patients with multiple concomitant pathologies present an increasing population of patients with nonhealing and problem wounds causing an unwelcome challenge for all health care providers. Many of these patients are not surgical candidates, or surgical procedures have failed to close their wounds. These wounds are particularly worrisome when an orthopaedic component is included, since bone and hardware must be covered as quickly as possible to prevent infection and even worse complications. We present a brief overview of several nonsurgical modalities that may be used to heal soft tissue wounds completely or to prepare the wound so a smaller surgical intervention may be done with greater chance for success. We include exogenous application of growth factors, cultured keratinocyte grafts, electrical stimulation, hyperbaric oxygen, and a vacuum-assisted closure system (V.A.C.).
人口迅速老龄化以及患有多种并存疾病的患者数量不断增加，导致不愈合和有问题伤口的患者群体日益庞大，这给所有医疗服务提供者带来了令人不快的挑战。这些患者中的许多人不适合进行手术，或者手术未能闭合他们的伤口。当涉及骨科植入物时，这些伤口尤其令人担忧，因为必须尽快覆盖骨骼和植入物以防止感染及更严重的并发症。我们简要概述几种非手术方法，这些方法可用于完全愈合软组织伤口或为伤口做准备，以便进行更小的手术干预并获得更大的成功机会。我们包括生长因子的外源性应用、培养的角质形成细胞移植、电刺激、高压氧和负压封闭引流系统（V.A.C.）。
