Effects of streptozotocin-induced diabetes on place conditioning action of cocaine in mice.

The effect of diabetes on the cocaine-induced place conditioning in mice was examined. In non-diabetic mice, cocaine, at dose ranges from 1 to 30 mg/kg, s.c. caused a dose-related preference for the drug-associated place, and significant place conditioning was observed at 10 and 30 mg/kg. In diabetic mice, cocaine at a dose of 10 mg/kg, s.c. did not produce a significant place preference, but a significant place conditioning was observed at 30 mg/kg. These results suggest that the reinforcing property of cocaine in diabetic mice was less than that in non-diabetic mice.