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哮喘的管理策略

Strategies for the management of asthma.

作者信息

Woolcock A J

机构信息

Institute of Respiratory Medicine, Sydney, New South Wales, Australia.

出版信息

Respirology. 1996 Jun;1(2):79-83. doi: 10.1111/j.1440-1843.1996.tb00015.x.

Abstract

The aims of treating patients with asthma are to relieve symptoms, to prevent symptoms and exacerbations, and to prevent long-term deterioration in lung function. It is the role of medical practitioners to inform the patient what asthma is, and to develop a plan to achieve the aims for the individual, recognizing that asthma is frequently a chronic, lifelong disease. Most patients can be diagnosed, assessed for severity and causes, and treated in primary care practices, however, sometimes help from an asthma clinic of a specialist is required. The most important management decision is to determine whether the patient needs inhaled corticosteroids; subsequently, decisions about dose, duration and method of delivery of treatment can be tailored to the individual depending on the preferences and social conditions of the patient. The aim of this article is to present the latest strategies for the management of asthma and the simplest methods for their implementation. Important new strategies include careful assessment of the severity; immediate introduction of a plan that is tailored of the individual and aimed at the possible reversing of the disease; detailed instructions for management of exacerbations and the combined use of inhaled corticosteroids with a long-acting bronchodilator. It is becoming clear that these strategies obviate dependence on oral corticosteroids in newly diagnosed asthmatic patients. Furthermore, relatively low doses of inhaled corticosteroids can be used to maintain good control if used in conjunction with other therapies. The role of newly developed antagonists to leukotrienes is not yet known but it may well be useful in mild asthma and in special forms of the disease, such as those sensitive to aspirin. In the future, the most important strategy will be to prevent the disease.

摘要

治疗哮喘患者的目标是缓解症状、预防症状及病情加重,并防止肺功能长期恶化。医生的职责是告知患者哮喘是什么,并制定一个计划以实现针对个体的目标,同时认识到哮喘通常是一种慢性的、终身性疾病。大多数患者可以在初级医疗诊所进行诊断、评估严重程度及病因并接受治疗,然而,有时需要专科哮喘诊所的帮助。最重要的管理决策是确定患者是否需要吸入性糖皮质激素;随后,可以根据患者的偏好和社会状况为个体量身定制关于治疗剂量、持续时间及给药方法的决策。本文的目的是介绍哮喘管理的最新策略及其实施的最简单方法。重要的新策略包括仔细评估严重程度;立即引入针对个体且旨在可能逆转疾病的计划;关于病情加重管理的详细说明以及吸入性糖皮质激素与长效支气管扩张剂的联合使用。越来越明显的是,这些策略避免了新诊断哮喘患者对口服糖皮质激素的依赖。此外,如果与其他疗法联合使用,相对低剂量的吸入性糖皮质激素可用于维持良好的控制。新开发的白三烯拮抗剂的作用尚不清楚,但它可能对轻度哮喘及特殊形式的疾病(如对阿司匹林敏感的疾病)有用。未来,最重要的策略将是预防该疾病。

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