Guidi-Rontani C, Duflot E, Mock M
Laboratoire de Génétique Moléculaire des Toxines, CNRS URA1858, Institut Pasteur, Paris, France.
FEMS Microbiol Lett. 1997 Dec 15;157(2):285-9. doi: 10.1111/j.1574-6968.1997.tb12786.x.
Bacillus anthracis lethal toxin (PALF) stimulated the proliferation of human peripheral blood T-cells in vitro. Activation of T-lymphocytes by PALF required the presence of monocytes and did not result from a collaborative effect between T-cells and B-cells. PALF acted directly on monocytes and independently of T-cells. The monocytes contributed to the proliferation of T-cells by secretion of mediator(s). The mitogenic activity of the lethal toxin was dependent on its metalloprotease activity.
炭疽杆菌致死毒素（PALF）在体外刺激人外周血T细胞增殖。PALF激活T淋巴细胞需要单核细胞的存在，并非T细胞与B细胞之间协同作用的结果。PALF直接作用于单核细胞，且不依赖于T细胞。单核细胞通过分泌介质促进T细胞增殖。致死毒素的促有丝分裂活性取决于其金属蛋白酶活性。
