D'Andrea V, Malinovsky L, Berni A, Biancari F, Biassoni L, Di Matteo F M, Corbellini L, Falvo L, Santoni F, Spyrou M, De Antoni E
3rd Department of General Surgery, University La Sapienza Rome, Italy.
G Chir. 1997 Oct;18(10):521-4.
The Authors studied the localization of protein gene product (PGP) 9.5-like immunoreactivity in normal human kidney tissue and compared the results with the same immunostaining in renal cell carcinoma. PGP 9.5-like immunoreactivity was found in cells of distal convoluted tubules and in some glomerular capillaries. The cells of proximal convoluted tubules did not show any immunostaining. Sections from renal cell carcinoma showed a very low immunostaining or were negative for PGP 9.5. As PGP 9.5 is a marker of the diffuse endocrine system, the Authors believe that the stained cells of distal tubules should be considered as neuroendocrine cells. The negative reaction to PGP 9.5 antibodies in renal cell carcinoma is rather surprising since not only tumours of neuroectodermal origin, but also tumours of other origin and tissues from some chronic degenerative diseases show a positive reaction. The explication of a negative reaction in renal cell carcinoma remains open: one of the possible explanations could be the specific histogenesis of this tumour.
作者研究了蛋白基因产物（PGP）9.5样免疫反应性在正常人体肾脏组织中的定位，并将结果与肾细胞癌中的相同免疫染色进行了比较。在远曲小管细胞和一些肾小球毛细血管中发现了PGP 9.5样免疫反应性。近曲小管细胞未显示任何免疫染色。肾细胞癌切片显示PGP 9.5免疫染色非常低或呈阴性。由于PGP 9.5是弥漫性内分泌系统的标志物，作者认为远曲小管的染色细胞应被视为神经内分泌细胞。肾细胞癌对PGP 9.5抗体的阴性反应相当令人惊讶，因为不仅神经外胚层起源的肿瘤，而且其他起源的肿瘤以及一些慢性退行性疾病的组织都显示出阳性反应。肾细胞癌阴性反应的解释仍然未知：一种可能的解释可能是该肿瘤的特定组织发生。
