Hosenfeld D, Paulsen H
Klin Padiatr. 1976 Jan;188(1):55-61.
It was intendet to characterize the isoenzymes of serum alkaline phosphatase in healthy infants. Quantitative estimation of the activity of serum alkaline phosphatase resulted in relatively low values in the newborns and a distinct increase during the first three months of live. As a rule most of the newborns appeared to present one uniform isoenzyme fraction, which was comparable to the isoenzyme of bone origin of the adult. Some of the newborns already exhibited another less marked isoenzyme, the isoenzyme of liver origin. During babyhood this isoenzyme becomes more and more distinct. In most cases this development had become perfect at the end of the first year. Liver tissue of newborns apparently does not synthesize the same liver isoenzyme as liver tissue of adults.
本研究旨在对健康婴儿血清碱性磷酸酶的同工酶进行特征描述。血清碱性磷酸酶活性的定量测定结果显示，新生儿的该酶活性相对较低，且在出生后的头三个月内显著升高。通常，大多数新生儿似乎呈现出一种单一的同工酶组分，这与成人骨源性同工酶相当。一些新生儿已经表现出另一种不太明显的同工酶，即肝源性同工酶。在婴儿期，这种同工酶变得越来越明显。在大多数情况下，这种发育在第一年末已趋于完善。新生儿的肝脏组织显然不能合成与成人肝脏组织相同的肝同工酶。
