Chen C P, Chern S R, Wang T Y, Huang Z D, Huang M C, Chuang C Y
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
Hum Reprod. 1997 Nov;12(11):2553-6. doi: 10.1093/humrep/12.11.2553.
We present two pregnancies associated with normal live births and the unusual concomitance of chorangioma and placental vascular malformation with mesenchymal hyperplasia. The enlarged placenta had the characteristic findings of chorangioma, dilated and varicose chorionic vessels and multiple vesicle-like villi containing hyaluronic acid. The vesicle-like villi showed diploid cellular DNA contents. Molecular genetic analysis using the polymerase chain reaction amplification of polymorphic microsatellite markers confirmed genetic identity among the chorangioma, the vesicle-like villi and the fetus. Both pregnancies were complicated by polyhydramnios, pre-term labour and prematurity. One neonate suffered from anaemia and thrombocytopenia. Another neonate suffered from haemangiomatosis. Our cases demonstrate that concomitant chorangioma and placental mesenchymal hyperplasia are genetically identical to the fetus and can coexist with a normal viable fetus. Since haemangiomas, chorangiomas, chorionic vessels and villi mesenchymal cells are all derived from the mesoderm, a combination of fetal haemangiomas, placental vascular malformation, chorangiomas and placental mesenchymal hyperplasia may represent a mixed form of congenital malformation of the mesoderm.
我们报告了两例妊娠，均为正常活产，同时伴有绒毛膜血管瘤、胎盘血管畸形及间叶细胞增生，情况较为罕见。增大的胎盘具有绒毛膜血管瘤的典型表现，即绒毛膜血管扩张、曲张，还有多个含有透明质酸的囊泡样绒毛。囊泡样绒毛显示二倍体细胞DNA含量。使用多态性微卫星标记的聚合酶链反应扩增进行分子遗传学分析，证实了绒毛膜血管瘤、囊泡样绒毛与胎儿之间的基因一致性。两例妊娠均并发羊水过多、早产和未足月产。一名新生儿患有贫血和血小板减少症。另一名新生儿患有血管瘤病。我们的病例表明，绒毛膜血管瘤与胎盘间叶细胞增生在基因上与胎儿相同，且可与正常存活胎儿共存。由于血管瘤、绒毛膜血管瘤、绒毛膜血管及绒毛间叶细胞均起源于中胚层，胎儿血管瘤、胎盘血管畸形、绒毛膜血管瘤及胎盘间叶细胞增生的组合可能代表了一种中胚层先天性畸形的混合形式。
