Guschmann M
Abteilung Paidopathologie und Plazentologie, Institut für Pathologie, Charité, Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Pathologe. 2002 Sep;23(5):389-91. doi: 10.1007/s00292-002-0560-2. Epub 2002 Aug 21.
We describe an unusual type of cellular chorangioma with a high rate of proliferating cells and mitosis and high expression of the growth factor BFGF. The tumor was observed in the placenta of a 26-year-old gravida 1 with help syndrome. The pregnancy was terminated at 35+5 weeks by elective caesarean section. Chorangiomas are hamartoma malformations of the placenta which in some cases may be large enough to influence the course of pregnancy and associated complications are hydramnion, gestosis or hemorrhage. Complications for the fetus are due to hemodynamic alterations caused by the formation of an arteriovenous shunt. Because the histogenesis of the tumor is still unknown, we examined the expression of the growth factors VEGF and BFGF. The number of cells with an expression of VEGF in placental tissue and in the chorangioma was uniform, but the number of cells with an expression of BFGF was much higher in the chorangioma than in the placenta. We conclude that BFGF may have an influence on the growth of chorangiomas. There was no difference between the chorangioma and the placenta in the rate of apoptosis-inhibited cells.
我们描述了一种不寻常类型的细胞性绒毛膜血管瘤，其增殖细胞和有丝分裂率高，且生长因子碱性成纤维细胞生长因子（BFGF）表达高。该肿瘤在一名患有HELP综合征的26岁初产妇的胎盘中被观察到。妊娠在35 + 5周时通过择期剖宫产终止。绒毛膜血管瘤是胎盘的错构瘤畸形，在某些情况下可能大到足以影响妊娠进程，相关并发症有羊水过多、妊娠中毒症或出血。对胎儿的并发症是由于动静脉分流形成引起的血流动力学改变。由于肿瘤的组织发生仍不清楚，我们检测了生长因子血管内皮生长因子（VEGF）和BFGF的表达。胎盘组织和绒毛膜血管瘤中表达VEGF的细胞数量是一致的，但绒毛膜血管瘤中表达BFGF的细胞数量比胎盘中高得多。我们得出结论，BFGF可能对绒毛膜血管瘤的生长有影响。绒毛膜血管瘤和胎盘在凋亡抑制细胞率方面没有差异。
