无症状携带母亲血清中的e抗原和抗-e作为乙肝病毒母婴传播阳性和阴性的指标。

e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants.

作者信息

Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y

出版信息

N Engl J Med. 1976 Apr 1;294(14):746-9. doi: 10.1056/NEJM197604012941402.

DOI:10.1056/NEJM197604012941402

Abstract

Testing of serum samples of 23 pregnant women who were asymptomatic carriers of hepatitis B surface antigen for e antigen and antibody to e with an immunodiffusion technic identified 10 mothers with e antigen and seven with e antibody. Their babies were tested for hepatitis B surface antigen in serum at intervals for more than 12 months. In all 10 babies born to e-antigen-positive mothers hepatitis B surface antigen developed and persisted through the observation period, and all 10 elder siblings of these newborn babies were found to be asymptomatic carriers. In remarkable contrast, all seven babies born to mothers positive for antibody to e escaped antigenemia, and none of their three elder siblings carried surface antigen. On the basis of these results, e antigen may be used as an indicator of transmission, and antibody to e as that of absence of transmission of hepatitis B virus from carrier mothers to children.

摘要

采用免疫扩散技术对23名无症状乙肝表面抗原携带者孕妇的血清样本进行e抗原和e抗体检测，结果发现10名母亲有e抗原，7名有e抗体。对她们的婴儿血清进行乙肝表面抗原检测，间隔时间超过12个月。在e抗原阳性母亲所生的10名婴儿中，乙肝表面抗原均出现并在观察期内持续存在，这些新生儿的10名年长同胞均为无症状携带者。与之形成显著对比的是，e抗体阳性母亲所生的7名婴儿均未发生抗原血症，其3名年长同胞均未携带表面抗原。基于这些结果，e抗原可作为传播的指标，而e抗体可作为乙肝病毒从携带者母亲向儿童传播与否的指标。