N-月桂酰-N,N-二甲基氧化胺对二肉豆蔻酰磷脂酰胆碱双层膜厚度的影响：小角中子散射研究
Effect of N-lauryl-N,N-dimethylamine N-oxide on dimyristoyl phosphatidylcholine bilayer thickness: a small-angle neutron scattering study.
作者信息
Dubnicková M, Kiselev M, Kutuzov S, Devínsky F, Gordeliy V, Balgavý P
机构信息
Faculty of Pharmacy, J. A. Comenius University, Bratislava, Slovakia.
出版信息
Gen Physiol Biophys. 1997 Jun;16(2):175-88.
Small-angle neutron scattering on large extruded unilamellar dimyristoyl phosphatidylcholine (DMPC) liposomes was used to determine the DMPC bilayer thickness dL and its change in the presence of N-lauryl-N,N-dimethylamine N-oxide (LDAO). At 36 degrees C, the values of dL are dL = 3.44 +/- 0.10 nm and dL = 2.90 +/- 0.10 nm in pure DMPC bilayers and in bilayers at DMPC:LDAO = 2:1 molar ratio, respectively. Using the specific volumes of DMPC and LDAO and supposing that the molecular volumes and surface areas in the bilayer are additive, the surface areas of DMPC (ADMPC) and of LDAO (ALDAO) were found to be at 36 degrees C: ADMPC = 0.644 +/- 0.018 nm2 and ALDAO = 0.25 +/- 0.05 nm2.
利用小角中子散射技术对大型挤压单层二肉豆蔻酰磷脂酰胆碱（DMPC）脂质体进行研究，以确定DMPC双层厚度dL及其在N-月桂酰-N,N-二甲基氧化胺（LDAO）存在时的变化。在36℃下，纯DMPC双层和DMPC与LDAO摩尔比为2:1的双层中，dL的值分别为dL = 3.44±0.10 nm和dL = 2.90±0.10 nm。利用DMPC和LDAO的比容，并假设双层中的分子体积和表面积具有加和性，发现在36℃时，DMPC（ADMPC）和LDAO（ALDAO）的表面积分别为：ADMPC = 0.644±0.018 nm²和ALDAO = 0.25±0.05 nm²。
Zotero 插件