Westhoff C, Truman C, Kalmuss D, Cushman L, Davidson A, Rulin M, Heartwell S
College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Contraception. 1998 Apr;57(4):237-40. doi: 10.1016/s0010-7824(98)00024-9.
Women enrolled in a multicenter prospective study were evaluated to identify any possible relationship between depressive symptoms and the use of contraceptives. Women choosing Depo-Provera (n = 495) were evaluated before starting these contraceptives and were reinterviewed 1 year later. Women who continued the method had lower depressive symptom scores at baseline than did the women who discontinued the method or who were lost to follow-up. Among the continuing Depo-Provera users, the depressive symptom scores improved slightly at 1 year (7.4 vs 6.7). Those subjects with the highest (i.e., worst) scores at enrollment demonstrated improved scores at follow-up.
参与一项多中心前瞻性研究的女性接受了评估，以确定抑郁症状与避孕药使用之间的任何可能关系。选择醋酸甲羟孕酮避孕针（Depo-Provera）的女性（n = 495）在开始使用这些避孕药之前接受了评估，并在1年后再次接受访谈。继续使用该方法的女性在基线时的抑郁症状评分低于停止使用该方法或失访的女性。在持续使用醋酸甲羟孕酮避孕针的使用者中，抑郁症状评分在1年时略有改善（7.4对6.7）。那些在入组时得分最高（即最差）的受试者在随访时评分有所改善。
