Berkowitz K, Reyes C, Saadat P, Kjos S L
Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, USA.
J Reprod Med. 1997 Dec;42(12):793-800.
To compare the biochemical maturation of the components of the lung profile according to gestational age between reliably dated gestational diabetic and nondiabetic pregnancies.
Lung maturation was compared in reliably dated pregnancies in 501 gestational diabetic women and 561 nondiabetic women. Lecithin/sphingomyelin ratio (L/S) and phosphatidylglycerol (PG) were evaluated by analysis of variance according to the presence or absence of diabetes and weeks of gestational age. The effect of gestational diabetes on fetal lung maturation was determined by analysis of variance.
The gestational diabetic group had no clinical or statistical differences in L/S ratios as compared to the nondiabetic patients at any gestational age. There were no differences in mean percent PG between the diabetic and nondiabetic groups at any gestational age. By 37 completed weeks, 86% of the L/S ratios and 78% of the PG values were mature in the diabetic group as compared to 80% of the L/S ratios and 78% of the PG values in the control group (P = .33 and .43, respectively).
In reliably dated gestational diabetic pregnancies, biochemical maturation of the fetal lung strongly correlates with gestational age and does not appear to be significantly delayed when compared to a nondiabetic control group.
比较孕周可靠的妊娠期糖尿病孕妇与非糖尿病孕妇肺部指标各成分的生化成熟度。
对501例妊娠期糖尿病孕妇和561例非糖尿病孕妇孕周可靠的妊娠情况进行肺部成熟度比较。根据是否患有糖尿病以及孕周，通过方差分析评估卵磷脂/鞘磷脂比值（L/S）和磷脂酰甘油（PG）。通过方差分析确定妊娠期糖尿病对胎儿肺成熟的影响。
在任何孕周，妊娠期糖尿病组与非糖尿病患者相比，L/S比值在临床和统计学上均无差异。在任何孕周，糖尿病组和非糖尿病组的平均PG百分比均无差异。到孕37足周时，糖尿病组86%的L/S比值和78%的PG值成熟，而对照组分别为80%的L/S比值和78%的PG值（P分别为0.33和0.43）。
在孕周可靠的妊娠期糖尿病妊娠中，胎儿肺生化成熟度与孕周密切相关，与非糖尿病对照组相比，似乎没有明显延迟。
