Krari N, Allain P
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
Biol Trace Elem Res. 1991 Nov;31(2):199-207. doi: 10.1007/BF02990428.
It is recognized that the development of hypertension in Dahl salt-sensitive (DS) rats as compared to Dahl salt-resistant (DR) rats is dependent on the addition of a high percentage of sodium chloride, often 8% to the diet. In this work, blood systolic pressure and the concentrations of many elements in different tissues of DS and DR rats were measured. However, to distinguish the modifications linked to the strain from the modifications owing to excess of sodium intake, no additional Na was included in the diet in all our experiments. Without any addition of sodium chloride to the diet, a statistically significant increase of the systolic blood pressure of DS rats (152 +/- 10 mmHg) in comparison to DR rats (131 +/- 3 mmHg) was observed. The analysis of the concentrations of many elements in different tissues showed no major modifications of sodium concentrations in DS rats as compared to DR rats, but a decrease of calcium in plasma (-9%), brain (-20%), and heart (-7%) and of magnesium in plasma (-13%), kidney (-11%), and bone (-7%). In conclusion, an increased intake of Na is not necessary to obtain a higher systolic blood pressure in DS rats compared to DR rats. Since we did not find noticeable modifications of Na concentration in tissues but modifications of Ca and Mg, we suggest that an alteration of the homeostasis of these two elements may be involved in the development of the hypertension in DS rats.
人们认识到，与达尔盐抵抗（DR）大鼠相比，达尔盐敏感（DS）大鼠高血压的发展取决于在饮食中添加高比例的氯化钠，通常为8%。在这项工作中，测量了DS和DR大鼠的收缩压以及不同组织中多种元素的浓度。然而，为了区分与品系相关的变化和由于钠摄入过量引起的变化，在我们所有的实验中，饮食中都没有额外添加钠。在饮食中不添加任何氯化钠的情况下，观察到与DR大鼠（131±3 mmHg）相比，DS大鼠的收缩压有统计学意义的升高（152±10 mmHg）。对不同组织中多种元素浓度的分析表明，与DR大鼠相比，DS大鼠的钠浓度没有重大变化，但血浆中钙（-9%）、脑（-20%）和心脏（-7%）以及血浆中镁（-13%）、肾脏（-11%）和骨骼（-7%）的含量降低。总之，与DR大鼠相比，DS大鼠不需要增加钠的摄入量就能获得更高的收缩压。由于我们没有发现组织中钠浓度有明显变化，但发现了钙和镁的变化，我们认为这两种元素的稳态改变可能与DS大鼠高血压的发展有关。
