Daniels J, Goodman A D
Am J Med. 1983 Jul;75(1):17-23. doi: 10.1016/0002-9343(83)91162-2.
In a retrospective study of 120 patients with surgically proved primary hyperparathyroidism, 71 patients who were normotensive and 49 patients (41 percent) who were either hypertensive at the time of parathyroidectomy or had a history of hypertension were compared. The mean serum calcium levels in the normotensive and hypertensive patients were very similar (11.6 +/- 0.1 [SEM] mg/dl, and 11.8 +/- 0.1), ruling against the hypothesis that hypercalcemia per se is the dominant cause of the hypertension of hyperparathyroidism. The mean serum creatinine levels in the two groups were also very similar (1.02 +/- 0.05 and 1.09 +/- 0.05 mg/dl), indicating that the hypertension of hyperparathyroidism is not the consequence of advanced renal parenchymal damage. The hypertensive patients did not have a significantly higher prevalence of urolithiasis. A review of the data in this and related studies leads to the conclusion that the hypertension of hyperparathyroidism is heterogeneous in origin. The mean serum phosphate level in the hypertensive patients was significantly lower than that in the normotensive patients (2.20 +/- 0.06 mg/dl versus 2.69 +/- 0.09 mg/dl, p less than 0.02), which may be due to a decrease in renal tubular phosphate reabsorption secondary to hypertension.
在一项对120例经手术证实的原发性甲状旁腺功能亢进患者的回顾性研究中，比较了71例血压正常的患者和49例（41%）在甲状旁腺切除时患有高血压或有高血压病史的患者。血压正常和高血压患者的平均血清钙水平非常相似（分别为11.6±0.1[标准误]mg/dl和11.8±0.1），这排除了高钙血症本身是甲状旁腺功能亢进患者高血压主要原因的假设。两组的平均血清肌酐水平也非常相似（分别为1.02±0.05和1.09±0.05mg/dl），表明甲状旁腺功能亢进患者的高血压不是晚期肾实质损害的结果。高血压患者尿路结石的患病率没有显著更高。对本研究及相关研究数据的回顾得出结论，甲状旁腺功能亢进患者的高血压病因是异质性的。高血压患者的平均血清磷水平显著低于血压正常患者（分别为2.20±0.06mg/dl和2.69±0.09mg/dl，p<0.02），这可能是由于高血压继发肾小管磷重吸收减少所致。
