Hetherington H P, Newcomer B R, Pan J W
Department of Medicine, University of Alabama at Birmingham, 35294, USA.
Magn Reson Med. 1998 Jan;39(1):6-10. doi: 10.1002/mrm.1910390103.
The goal of this work was to develop and evaluate a numerically optimized inversion pulse to be used with a homonuclear editing sequence to measure human cerebral GABA in vivo at 4.1 T in the occipital lobe. The optimized pulse was constructed using pallindromic symmetry with 30 pulses and 29 delays. The optimized pulse provided greater selectivity than the equivalent bandwidth matched DANTE pulse and sinc shaped DANTE. The improved selectivity reduced the co-editing of the macromolecule resonance, permitting the GABA edited doublet to be resolved in vivo. Using cerebral creatine as a reference, 7.1 mM, the measured GABA level was 1.15 +/- 0.13 mM in the occipital lobe.
这项工作的目标是开发并评估一种数值优化的反转脉冲，该脉冲将与同核编辑序列一起使用，以在4.1T磁场下于枕叶对人体大脑中的γ-氨基丁酸（GABA）进行活体测量。优化后的脉冲利用30个脉冲和29个延迟构建而成，具有回文对称性。与等效带宽匹配的DANTE脉冲和sinc形DANTE相比，优化后的脉冲具有更高的选择性。选择性的提高减少了大分子共振的共编辑，使得GABA编辑双峰能够在活体中得到分辨。以脑肌酸作为参考（浓度为7.1 mM），枕叶中测得的GABA水平为1.15±0.13 mM。
