Varela S, Subiza J, Subiza J L, Rodríguez R, García B, Jerez M, Jiménez J A, Panzani R
General Pardiñas Center of Asthma and Allergy, Madrid, Spain.
J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):748-54. doi: 10.1016/s0091-6749(97)70268-9.
The existence of Platanus pollinosis is not generally accepted despite the production of very large quantities of airborne Platanus pollen in many cities of the United States and Europe. The aim of this study was to investigate if Platanus pollen really contributes to the symptoms of the patients with pollinosis in the Madrid area.
We carried out systematic skin prick testing with Platanus pollen extract on 47 patients seen in our allergy center with spring-summer pollinosis symptoms. Each patient maintained symptom score diaries before, during, and after the Platanus pollination season. The average symptom scores were calculated and compared with the Platanus pollen counts. Measurements of specific IgE by ELISA and immunoblotting also were performed in each patient.
The Platanus skin tests were positive in 33 of the 39 patients first seen with seasonal symptoms during Platanus pollen season and only in three of the eight patients without symptoms during Platanus exposure (Fisher's exact test; p < 0.05). Twenty-two of the 33 Platanus-positive skin test patients also had a positive ELISA result. Furthermore, the average 24-hour rhinitis symptom scores of the 39 patients first seen with seasonal symptoms during March through April showed significant correlation with Platanus pollen counts (r(s) = 0.57, p < 0.05). The immunoblot results suggest that a 17 kd pollen protein could be a major allergen in patients with Platanus pollinosis.
Platanus pollen is an important cause of pollinosis in Madrid. A protein with a molecular weight of 17 kd appeared to be its major allergen.
尽管在美国和欧洲的许多城市中产生了大量的悬铃木花粉，但悬铃木花粉症的存在尚未得到普遍认可。本研究的目的是调查悬铃木花粉是否真的会导致马德里地区花粉症患者出现症状。
我们对在过敏中心就诊的47例有春夏花粉症症状的患者进行了悬铃木花粉提取物的系统性皮肤点刺试验。每位患者在悬铃木授粉季节之前、期间和之后记录症状评分日记。计算平均症状评分并与悬铃木花粉计数进行比较。还对每位患者进行了ELISA和免疫印迹法检测特异性IgE。
在悬铃木花粉季节首次出现季节性症状的39例患者中，有33例悬铃木皮肤试验呈阳性，而在悬铃木暴露期间无症状的8例患者中只有3例呈阳性（Fisher精确检验；p<0.05）。33例悬铃木皮肤试验阳性的患者中有22例ELISA结果也呈阳性。此外，3月至4月首次出现季节性症状的39例患者的平均24小时鼻炎症状评分与悬铃木花粉计数显著相关（r(s)=0.57，p<0.05）。免疫印迹结果表明，一种17kd的花粉蛋白可能是悬铃木花粉症患者的主要过敏原。
悬铃木花粉是马德里花粉症的重要病因。一种分子量为17kd的蛋白质似乎是其主要过敏原。
