Wang Y, DuBois J L, Hedman B, Hodgson K O, Stack T D
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
Science. 1998 Jan 23;279(5350):537-40. doi: 10.1126/science.279.5350.537.
Biomimetic functional models of the mononuclear copper enzyme galactose oxidase are presented that catalytically oxidize benzylic and allylic alcohols to aldehydes with O2 under mild conditions. The mechanistic fidelity between the models and the natural system is pronounced. Modest structural mimicry proves sufficient to transfer an unusual ligand-based radical mechanism, previously unprecedented outside the protein matrix, to a simple chemical system.
本文提出了单核铜酶半乳糖氧化酶的仿生功能模型，该模型在温和条件下能以氧气将苄醇和烯丙醇催化氧化为醛。模型与天然体系之间的机理相似性十分显著。适度的结构模拟已证明足以将一种基于配体的独特自由基机理（此前在蛋白质基质之外从未有过）转移至一个简单的化学体系。
