Glick R P, Lichtor T, Unterman T G
Department of Anatomy and Cell Biology, Neurosurgery, Cook County Hospital, Chicago, Illinois, USA.
J Neurooncol. 1997 Dec;35(3):315-25. doi: 10.1023/a:1005876819455.
Insulin-like growth factors (IGFs) appear to play a role in the development of tumors in general and brain tumors in particular. Specific receptors for IGFs have been identified in normal human and rat brain, and evidence suggests that components of the IGF signal transduction system may play a role in the transformation process. Secretion of IGFs by a variety of human brain tumors has been confirmed, and these growth factors appear to have an autocrine stimulatory effect on these tumors. IGFs circulate in the blood stream bound to at least six distinct binding proteins which may modulate the effects of these growth factors on target tissues. Sex steroids may also regulate the behavior of certain brain tumors such as meningiomas at least in part through their effects on the expression of IGFs and their binding proteins. Recently, antisense gene technology against certain IGFs or their receptors have resulted in potent antitumor effects in the case of several gliomas, although the mechanism for this remains unclear.
胰岛素样生长因子（IGFs）似乎在肿瘤的发生发展中发挥作用，尤其是在脑肿瘤中。在正常人和大鼠脑中已鉴定出IGFs的特异性受体，并且有证据表明IGF信号转导系统的成分可能在转化过程中起作用。多种人脑肿瘤分泌IGFs已得到证实，并且这些生长因子似乎对这些肿瘤具有自分泌刺激作用。IGFs在血液中与至少六种不同的结合蛋白结合循环，这些结合蛋白可能调节这些生长因子对靶组织的作用。性类固醇也可能至少部分地通过其对IGFs及其结合蛋白表达的影响来调节某些脑肿瘤（如脑膜瘤）的行为。最近，针对某些IGFs或其受体的反义基因技术在几种胶质瘤中产生了强大的抗肿瘤作用，尽管其机制尚不清楚。
