维生素E与西咪替丁对腹膜炎诱导的脂质过氧化的影响。

Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation.

作者信息

Tuncel P, Gür E S, Kaya E, Ozbek R, Oztürk E, Tokyay R

机构信息

Uludağ University Faculty of Medicine, Department of Biochemistry, Bursa, Turkey.

出版信息

Res Exp Med (Berl). 1997;197(4):235-41. doi: 10.1007/s004330050072.

DOI:10.1007/s004330050072

PMID:9440141

Abstract

To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.

摘要

为研究急性粪便性腹膜炎对血浆和组织脂质过氧化的影响以及维生素E（Vit E）和西咪替丁在大鼠腹膜炎模型中4小时时可能的保护作用，将四组设定为：对照组、腹膜炎组、Vit E组和西咪替丁组。测量血浆、肝脏、肺和肾脏中的硫代巴比妥酸反应物质（TBARS）和共轭二烯（CD）水平以监测氧化损伤。当前的粪便性腹膜炎模型导致肝脏TBARS显著升高；然而，Vit E和西咪替丁均未能有效预防TBARS的形成。给予Vit E和西咪替丁可使肝脏和肺中CD水平较腹膜炎组的值显著降低。