Wildberger J E, Mull M, Kilbinger M, Schön S, Vorwerk D
Klinik für Radiologische Diagnostik, Universitätsklinikum der RWTH Aachen.
Rofo. 1997 Nov;167(5):527-9. doi: 10.1055/s-2007-1015575.
To perform an initial evaluation of the accuracy in detection of dural sinus and cerebral venous thrombosis using a bed-side test (SimpliRED).
Early diagnosis and treatment of cerebral sinus thrombosis are important. A screening test to decide which patients should undergo further diagnostics would be valuable due to the low incidence. Six patients with MR proven cerebral sinus thrombosis underwent bed-side testing. The SimpliRED kit provides a clearly visible agglutination of the patient's red blood cells in the presence of elevated levels of the crosslinked fibrin derivative (D-dimer) in the sample.
The assay yielded a positive result in all six patients, even 56 days following the onset of clinical symptoms.
The sensitivity of SimpliRED in the detection of sinus venous thrombosis is not known. This assay, therefore, should be evaluated in a large prospective study. In addition, the capability of the test to assess the effect of and predict the duration of anticoagulation therapy should be considered.
使用床旁检测（SimpliRED）对硬脑膜窦和脑静脉血栓形成的检测准确性进行初步评估。
脑窦血栓形成的早期诊断和治疗很重要。由于发病率低，进行一项筛选试验以确定哪些患者应接受进一步诊断将很有价值。6例经磁共振成像证实为脑窦血栓形成的患者接受了床旁检测。SimpliRED试剂盒在样本中交联纤维蛋白衍生物（D-二聚体）水平升高时会使患者红细胞出现明显可见的凝集。
该检测在所有6例患者中均产生阳性结果，甚至在临床症状出现56天后也是如此。
SimpliRED在检测窦静脉血栓形成方面的敏感性尚不清楚。因此，应在一项大型前瞻性研究中对该检测进行评估。此外，应考虑该检测评估抗凝治疗效果和预测抗凝治疗持续时间的能力。
