Wallace D K, Plager D A, Snyder S K, Raiesdana A, Helveston E M, Ellis F D
Department of Ophthalmology, University of North Carolina at Chapel Hill, USA.
Ophthalmology. 1998 Jan;105(1):101-11. doi: 10.1016/s0161-6420(98)91519-6.
This study aimed to describe results of glaucoma surgeries performed at one institution over the past 20 years in children with aphakia, aniridia, anterior segment dysgenesis, and other secondary glaucomas.
The study design was a retrospective review.
Fifty-eight eyes of 40 patients were studied.
Trabeculectomy with or without mitomycin C, Molteno implantation, goniotomy, sclerostomy, endolaser cyclophotocoagulation, and cyclocryotherapy were performed.
Intraocular pressure (IOP) control, defined as complete success (IOP < or = 21 without medications) or qualified success (IOP < or = 25 without medications or IOP < or = 21 with medications) and postoperative visual acuity stability were assessed.
One hundred thirty surgical procedures were performed on 58 eyes of 40 patients; follow-up averaged 7.3 years. Intraocular pressure control was achieved in 40 (70%) of 57 eyes after 1 or more procedures. Intraocular pressure control and stabilization of visual acuity and optic disc appearance were achieved in 28 (51%) of 55 eyes. Five eyes had significant postoperative complications. Trabeculectomy with mitomycin C controlled IOP on last visit in 8 of 13 eyes with aphakic glaucoma.
Surgical intervention can control IOP and prevent visual loss in children with secondary glaucomas. In the authors' experience, a filtering procedure is the most effective treatment in aphakic glaucoma and anterior segment dysgenesis.
本研究旨在描述过去20年在一家机构为无晶状体、无虹膜、前段发育异常及其他继发性青光眼患儿实施青光眼手术的结果。
本研究设计为回顾性研究。
对40例患者的58只眼进行了研究。
实施了小梁切除术(使用或不使用丝裂霉素C)、莫尔顿植入术、前房角切开术、巩膜切开术、眼内激光睫状体光凝术和睫状体冷凝术。
评估眼压(IOP)控制情况,定义为完全成功(不用药时IOP≤21)或合格成功(不用药时IOP≤25或用药时IOP≤21)以及术后视力稳定性。
对40例患者的58只眼实施了130次手术;平均随访7.3年。57只眼中有40只(70%)在1次或多次手术后眼压得到控制。55只眼中有28只(51%)眼压得到控制且视力和视盘外观稳定。5只眼出现了严重的术后并发症。在13只无晶状体性青光眼眼中,8只在最后一次随访时使用丝裂霉素C的小梁切除术控制了眼压。
手术干预可控制继发性青光眼患儿的眼压并预防视力丧失。根据作者的经验,滤过手术是治疗无晶状体性青光眼和前段发育异常最有效的方法。