Dutta A, Bell S P
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Annu Rev Cell Dev Biol. 1997;13:293-332. doi: 10.1146/annurev.cellbio.13.1.293.
The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.
最近对识别DNA复制起点并控制真核生物DNA复制起始的蛋白质的鉴定，为剖析这一过程提供了关键的分子工具。复制起点处蛋白质复合物组装和解聚的动态变化对DNA复制的起始很重要，并且在整个细胞周期中都会发生。在此，我们综述DNA复制起始所需的关键蛋白质、它们在复制起点处蛋白质复合物组装中的作用，以及细胞周期机制如何调控这一过程。
