Golub T R
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Hematol Oncol Clin North Am. 1997 Dec;11(6):1207-20. doi: 10.1016/s0889-8588(05)70490-1.
The TEL gene is a recently described, "promiscuous" gene with a role in both myeloid and lymphoid malignancy. It is unusual since there may be more than one mechanism by which its rearrangement through chromosomal translocation is leukemogenic. This article discusses the four potential mechanisms of TEL-mediated transformation. It is conceivable that the TEL gene is the common target for various translocations precisely because of this pleiotropy of pathogenic mechanisms by which TEL gene rearrangements can lead to cell transformation.
TEL基因是最近描述的一种“混杂”基因，在髓系和淋巴系恶性肿瘤中均起作用。它不同寻常之处在于，其通过染色体易位发生重排从而导致白血病发生的机制可能不止一种。本文讨论了TEL介导的转化的四种潜在机制。可以想象，正是由于TEL基因重排可导致细胞转化的致病机制具有多效性，TEL基因才成为各种易位的共同靶点。
