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Signaling in leukemia: which messenger to kill?

作者信息

Pear W S

机构信息

University of Pennsylvania, Department of Pathology, Institute for Medicine and Engineering, 611 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104-6160, USA.

出版信息

J Clin Invest. 2000 Feb;105(4):419-22. doi: 10.1172/JCI9461.

DOI:10.1172/JCI9461
PMID:10683370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC289178/
Abstract
摘要

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Signaling in leukemia: which messenger to kill?白血病中的信号传导：该阻断哪个信使分子？
J Clin Invest. 2000 Feb;105(4):419-22. doi: 10.1172/JCI9461.
2
Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.由TEL/PDGFβR表达在小鼠中诱导产生的致命性骨髓增殖依赖于PDGFβR的酪氨酸579/581。
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3
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines.p210BCR/ABL、p190BCR/ABL和TEL/ABL在造血细胞系中激活相似的信号转导途径。
Oncogene. 1996 Sep 19;13(6):1147-52.
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The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.慢性粒单核细胞白血病中的TEL/血小板衍生生长因子β受体（PDGFβR）融合蛋白是一种具有转化能力的蛋白，它能自我缔合并激活依赖于PDGFβR激酶的信号通路。
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Involvement of the TEL gene in hematologic malignancy by diverse molecular genetic mechanisms.TEL基因通过多种分子遗传机制参与血液系统恶性肿瘤。
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ETV6: a versatile player in leukemogenesis.ETV6：白血病发生过程中的多面手。
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Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.在伴有t(5;12)染色体易位的慢性粒单核细胞白血病中，血小板衍生生长因子受体β与一个新的ets样基因tel融合。
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Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.E2A-HLF对CD33表达的特异性诱导：融合转录因子导致急性淋巴细胞白血病中异常髓系抗原表达的首个证据。
Leukemia. 2010 Apr;24(4):865-9. doi: 10.1038/leu.2010.8. Epub 2010 Feb 11.
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TEL/AML1 shows dominant-negative effects over TEL as well as AML1.TEL/AML1对TEL以及AML1显示出显性负效应。
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Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.锚蛋白重复序列和反式激活结构域在Notch1诱导T细胞白血病中的重要作用。
Mol Cell Biol. 2000 Oct;20(20):7505-15. doi: 10.1128/MCB.20.20.7505-7515.2000.

本文引用的文献

1
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase.Grb2结合位点是Bcr/Abl酪氨酸激酶在小鼠中诱导慢性髓性白血病样疾病所必需的。
Blood. 2000 Jul 15;96(2):664-70.
2
Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.由TEL/PDGFβR表达在小鼠中诱导产生的致命性骨髓增殖依赖于PDGFβR的酪氨酸579/581。
J Clin Invest. 2000 Feb;105(4):423-32. doi: 10.1172/JCI8902.
3
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia.从一种用于慢性粒细胞白血病的 Abl 酪氨酸激酶抑制剂的研发中吸取的经验教训。
J Clin Invest. 2000 Jan;105(1):3-7. doi: 10.1172/JCI9083.
4
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.生长因子受体激活的多种信号通路会诱导出广泛重叠而非独立的基因集。
Cell. 1999 Jun 11;97(6):727-41. doi: 10.1016/s0092-8674(00)80785-0.
5
The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity.BCR/ABL癌基因的P190、P210和P230形式在小鼠中诱导出类似慢性髓性白血病的综合征，但具有不同的淋巴细胞白血病致瘤活性。
J Exp Med. 1999 May 3;189(9):1399-412. doi: 10.1084/jem.189.9.1399.
6
TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor.TEL/PDGFβR在小鼠中诱导出对特定酪氨酸激酶抑制剂有反应的血液系统恶性肿瘤。
Blood. 1999 Mar 1;93(5):1707-14.
7
Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia.Bcr-Abl可有效诱导小鼠发生骨髓增殖性疾病，并产生过量的白细胞介素-3和粒细胞-巨噬细胞集落刺激因子：一种慢性粒细胞白血病的新模型。
Blood. 1998 Nov 15;92(10):3829-40.
8
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.在接受P210 bcr/abl转导骨髓的小鼠中高效快速诱导慢性粒细胞白血病样骨髓增殖性疾病
Blood. 1998 Nov 15;92(10):3780-92.
9
Signal transduction via platelet-derived growth factor receptors.通过血小板衍生生长因子受体的信号转导。
Biochim Biophys Acta. 1998 Aug 19;1378(1):F79-113. doi: 10.1016/s0304-419x(98)00015-8.
10
TEL gene rearrangements in myeloid malignancy.髓系恶性肿瘤中的TEL基因重排
Hematol Oncol Clin North Am. 1997 Dec;11(6):1207-20. doi: 10.1016/s0889-8588(05)70490-1.