Lakke J P, Teelken A W
Neurology. 1976 May;26(5):489-93. doi: 10.1212/wnl.26.5.489.
Free amino acid determinations in the cerebrospinal fluid of patients with Parkinson's disease or other extrapyramidal disorders showed that in both groups most amino acids were increased. Significantly increased amino acids were neutral and basic amino acids. Amino acid clusters were present and corresponded with the grouping of amino acids in accordance with amino acid transport systems. The amino acids within the clusters showed a remarkable degree of correlation, and there was a notable correlation between the clusters both in the parkinsonian group and in the group of extrapyramidal disorders, but not in a control group. Our data suggest that in a number of extrapyramidal disorders, Parkinson's disease included, a more generalized abnormality exists than neuronal loss only and, in addition, that patients with these neurologic conditions have a common biochemical defect in their amino acid transport systems.
对帕金森病或其他锥体外系疾病患者脑脊液中的游离氨基酸进行测定，结果显示两组中大多数氨基酸含量均升高。显著升高的氨基酸为中性和碱性氨基酸。存在氨基酸簇，且这些簇与根据氨基酸转运系统对氨基酸的分组相对应。簇内的氨基酸显示出显著的相关性，在帕金森病组和锥体外系疾病组中，这些簇之间均存在显著相关性，但在对照组中则不存在。我们的数据表明，在包括帕金森病在内的多种锥体外系疾病中，存在比单纯神经元丢失更为广泛的异常情况，此外，患有这些神经系统疾病的患者在其氨基酸转运系统中存在共同的生化缺陷。
