Waller P J
Vet Parasitol. 1987 Jul;25(2):177-91. doi: 10.1016/0304-4017(87)90103-8.
Anthelmintic resistance has emerged as the most important problem confronting the successful control of nematode parasites of grazing animals. Although the significance of the problem varies between, and within, countries and farming enterprises, there is little likelihood that it will disappear of its own accord. On the contrary, it is reasonable to assume that it will increase if there is no change in traditional methods of parasite control. Although progress is being made in non-chemotherapeutic methods of control, these are unlikely to provide any practical alternatives in the short-term future. Nor can the pharmaceutical industry be expected to solve the problem because of the long period and the exceedingly high costs involved in bringing a completely new class of drug on to the market. The answer must lie in carefully husbanding the currently available anthelmintics, by providing farmers with programs which give good levels of parasite control and maintain high productivity in animals with fewer anthelmintic treatments. To be enthusiastically adopted by farmers, the programs require a commitment by both research and advisory workers. Such success can be achieved, as exemplified by the "Drenchplan" and "Wormkill" programs in Australia. It behoves workers in all countries which have a significant grazing livestock industry, not only those with an existing resistance problem, to consider how such schemes could be implemented.
抗蠕虫药耐药性已成为成功控制放牧动物线虫寄生虫面临的最重要问题。尽管该问题的严重程度在不同国家和养殖企业之间及内部存在差异，但它自行消失的可能性微乎其微。相反，如果寄生虫控制的传统方法不改变，那么可以合理地推测耐药性将会增加。尽管在非化学治疗控制方法方面正在取得进展，但在短期内这些方法不太可能提供任何实际的替代方案。由于将全新一类药物推向市场需要很长时间且成本极高，也不能期望制药行业解决这个问题。答案必定在于谨慎管理目前可用的驱虫药，为农民提供能有效控制寄生虫且在减少驱虫药使用次数的情况下保持动物高生产力的方案。要让农民积极采用这些方案，研究人员和咨询人员都需要做出承诺。澳大利亚的“驱虫计划”和“灭虫计划”就是成功的范例。所有拥有大量放牧牲畜产业的国家，不仅是那些存在现有耐药性问题的国家，其工作人员都应该考虑如何实施这类方案。
