Lozza A, Pepin J L, Rapisarda G, Moglia A, Delwaide P J
University Department of Neurology, Hôpital de la Citadelle, Liège, Belgium.
J Neural Transm (Vienna). 1997;104(6-7):679-87. doi: 10.1007/BF01291885.
Recovery curves of the R2 component of the blink reflex have been studied in 10 control subjects and 13 parkinsonian patients both after ipsilateral paired stimulation of the supraorbital nerve and after index finger stimulation. In control subjects, both types of conditioning induced a comparable marked inhibition lasting more than 600 ms. In parkinsonian patients, inhibition was reduced after both conditionings. However, differences appeared in the magnitude of the changes: after paired stimulation, it was less significant (ANOVA and post-hoc Duncan's test: p = 0.04) than after index finger stimulation (p = 0.002). In that latter situation, the more marked reduction in inhibition is interpreted, in the light of current physiologic knowledge, by hypoactivity of the Nucleus Reticularis Giganto Cellularis (NRGC) which would make less efficient inhibitory interneurones in the trigemino-facial pathway. The results are thus compatible with the suggestion that NRGC is made indirectly less active in Parkinson's disease.
在10名对照受试者和13名帕金森病患者中，研究了在同侧眶上神经配对刺激后以及食指刺激后眨眼反射R2成分的恢复曲线。在对照受试者中，两种类型的条件刺激均诱导出持续超过600毫秒的相当明显的抑制。在帕金森病患者中，两种条件刺激后抑制均减弱。然而，变化幅度出现了差异：配对刺激后，抑制减弱的程度（方差分析和事后邓肯检验：p = 0.04）不如食指刺激后显著（p = 0.002）。根据目前的生理学知识，在后一种情况下，抑制作用更明显的减弱被解释为巨细胞网状核（NRGC）活动减弱，这会使三叉神经-面神经通路中的抑制性中间神经元效率降低。因此，这些结果与帕金森病中NRGC间接活动减弱的观点相符。
