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Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity.

作者信息

Farber N B, Price M T, Labruyere J, Nemnich J, St Peter H, Wozniak D F, Olney J W

机构信息

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.

出版信息

Biol Psychiatry. 1993;34(1-2):119-21. doi: 10.1016/0006-3223(93)90265-f.

DOI:10.1016/0006-3223(93)90265-f
PMID:8373932
Abstract
摘要

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Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity.抗精神病药物可阻断苯环利定受体介导的神经毒性。
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Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: relevance to animal models of antipsychotic drugs.重复使用抗精神病药物治疗会逐渐增强对苯环己哌啶诱导的运动亢进的抑制作用,但会减弱对苯丙胺诱导的运动亢进的抑制作用:与抗精神病药物的动物模型的相关性。
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Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat.氯氮平、硫利达嗪和氟哌啶醇亚慢性给药对大鼠锥体外系运动功能相关测试的影响。
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Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs.氟哌啶醇和胃复安可阻断单向条件性回避反应的习得,但硫利达嗪或氯氮平则不然:这对筛选新型抗精神病药物具有启示意义。
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