Thakar Y S, Chande C, Dhanvijay A G, Shrikhande A V, Saoji A M
Department of Microbiology, Government Medical College, Nagpur.
Indian J Pathol Microbiol. 1997 Oct;40(4):559-61.
We hereby report two cases of Bisalbuminemia for its extreme rarity in Indian literature. In an attempt to look for 'M' component, polyacrylamide gel disc electrophoresis of serum displayed observation. The saline eluates of the slower (variant in our cases) and the faster component showed a reaction of complete identify in the agar gel double diffusion test when tested against monospecific antialbumin antibody. The immunoelectrophoretic analysis also confirmed the antigenic similarity between the two fractions. A wider use of disc electrophoresis perhaps would disclose additional cases of Bisalbuminemia in normals and in disease states.
鉴于双白蛋白血症在印度文献中极为罕见，我们在此报告两例该病症。为了寻找“M”成分，对血清进行了聚丙烯酰胺凝胶圆盘电泳观察。当针对单特异性抗白蛋白抗体进行检测时，较慢泳动组分（在我们的病例中为变异体）和较快泳动组分的盐析洗脱物在琼脂凝胶双向扩散试验中显示出完全一致的反应。免疫电泳分析也证实了这两个组分之间的抗原相似性。更广泛地应用圆盘电泳或许会在正常人和疾病状态中发现更多双白蛋白血症病例。
