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维斯那病毒dUTP酶对神经致病性并非必需。

Visna virus dUTPase is dispensable for neuropathogenicity.

作者信息

Pétursson G, Turelli P, Matthíasdóttir S, Georgsson G, Andrésson O S, Torsteinsdóttir S, Vigne R, Andrésdóttir V, Gunnarsson E, Agnarsdóttir G, Quérat G

机构信息

Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavik.

出版信息

J Virol. 1998 Feb;72(2):1657-61. doi: 10.1128/JVI.72.2.1657-1661.1998.

DOI:10.1128/JVI.72.2.1657-1661.1998
PMID:9445073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC124651/
Abstract

The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable. The dUTPase gene is dispensable for induction of lesions in the brain.

摘要

维斯纳病毒基因组中编码dUTPase的区域大部分被删除。与注射野生型病毒相比，脑内注射突变病毒导致病毒载量有所降低，尤其是在肺部，但神经致病作用相当。dUTPase基因对于脑部病变的诱导并非必需。

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本文引用的文献

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dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.缺乏脱氧尿苷三磷酸酶的山羊关节炎-脑炎病毒在致病性方面减毒，并积累了从鸟嘌呤到腺嘌呤的替换。
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In vivo and in vitro infection with two different molecular clones of visna virus.用两种不同分子克隆的维斯纳病毒进行体内和体外感染。
Virology. 1997 Mar 17;229(2):370-80. doi: 10.1006/viro.1996.8428.
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Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses.山羊和绵羊慢病毒dUTPase缺陷型突变体的复制特性
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Molecular cloning and characterization of deoxyuridine triphosphatase from feline immunodeficiency virus (FIV).猫免疫缺陷病毒（FIV）脱氧尿苷三磷酸酶的分子克隆与特性分析
Virology. 1993 Oct;196(2):451-7. doi: 10.1006/viro.1993.1501.
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Vaccinia virus encodes a functional dUTPase.痘苗病毒编码一种功能性脱氧尿苷三磷酸酶。
Virology. 1993 Aug;195(2):863-5. doi: 10.1006/viro.1993.1446.
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