维斯那病毒dUTP酶对神经致病性并非必需。
Visna virus dUTPase is dispensable for neuropathogenicity.
作者信息
Pétursson G, Turelli P, Matthíasdóttir S, Georgsson G, Andrésson O S, Torsteinsdóttir S, Vigne R, Andrésdóttir V, Gunnarsson E, Agnarsdóttir G, Quérat G
机构信息
Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavik.
出版信息
J Virol. 1998 Feb;72(2):1657-61. doi: 10.1128/JVI.72.2.1657-1661.1998.
Abstract
The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable. The dUTPase gene is dispensable for induction of lesions in the brain.
摘要
维斯纳病毒基因组中编码dUTPase的区域大部分被删除。与注射野生型病毒相比，脑内注射突变病毒导致病毒载量有所降低，尤其是在肺部，但神经致病作用相当。dUTPase基因对于脑部病变的诱导并非必需。
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