Djaldetti M, Malik Z, Lewinski U
Scand J Haematol. 1979 Nov;23(5):393-402. doi: 10.1111/j.1600-0609.1979.tb02739.x.
The cells of a patient with chronic lymphocytic leukaemia (CLL) showed a peculiar phenomenon of nuclear blebbing and nuclear extrusion, observed by transmission (TEM) and scanning (SEM) electron microscopy. Protein synthesis of the lymphocytes was 3 times higher than that of cells of other 3 patients with CLL, but was lower than the synthesis of cells from a patient with acute lymphoblastic leukaemia (ALL). Similar results were observed when RNA synthesizing activity of the cells was examined. On the other hand, thymidine incorporation proceeded in a similar rate in the patient's and the ALL lymphocytes, whereas in those CLL patients it was merely detected. The morphological findings and the synthesizing activities of the cells suggest that the patient's disease represents an intermediate form between CLL and ALL.
通过透射电子显微镜（TEM）和扫描电子显微镜（SEM）观察发现，一名慢性淋巴细胞白血病（CLL）患者的细胞呈现出核起泡和核挤出的特殊现象。该淋巴细胞的蛋白质合成比其他3名CLL患者的细胞高3倍，但低于一名急性淋巴细胞白血病（ALL）患者细胞的合成水平。检测细胞的RNA合成活性时也观察到了类似结果。另一方面，该患者和ALL淋巴细胞中胸苷掺入的速率相似，而在那些CLL患者中仅检测到了胸苷掺入。细胞的形态学发现和合成活性表明，该患者的疾病代表了CLL和ALL之间的一种中间形式。
