Vivas S, Rodríguez M, Palacio M A, Cadenas F, Lomo J, Rodrigo L
Servicio de Aparato Digestivo, Hospital Central de Asturias, Oviedo.
Gastroenterol Hepatol. 1997 Nov;20(9):456-8.
Oral terbinafine is a recently introduced antifungal drug with slight side effects that rarely includes liver involvement. A case of toxic hepatitis secondary to terbinafine administration in a patient with no previous history of liver disease and in whom other possible causes of liver damage and histologic study were performed is reported. A mixed lesion was presented with predominance of cholestasis. The initial worsening following discontinuation of the drug is of note as are the prolonged course of the enzymatic alterations which normalized at one year. The precise mechanism by which terbinafine produced liver damage is unknown and is probably due to an idiosyncratic type reaction.
口服特比萘芬是一种最近引入的抗真菌药物，副作用轻微，很少累及肝脏。本文报告了一例在无肝脏疾病史且已对其他可能的肝损伤原因进行了组织学研究的患者中，因服用特比萘芬继发中毒性肝炎的病例。该病例呈现以胆汁淤积为主的混合性病变。值得注意的是，停药后病情最初恶化，酶学改变病程延长，且在一年后恢复正常。特比萘芬导致肝损伤的确切机制尚不清楚，可能是一种特异质性反应。
