Milstein V, Small J G, Shelbourne D, Small I F
Dis Nerv Syst. 1976 Jul;37(7):373-5.
Fifty-six carefully diagnosed manic-depressive patients were evaluated seeking a relationship between onset of the illness, diurnal temperature variation, and month and season of birth. With respect to diurnal temperature variation, we were able to discover no significant change in the difference between the high and low temperature as the time of onset of each episode of the illness approached, but there was a trend for the high-low temperature difference to decrease as time of onset approached. Occurrence of episodes was seasonally distributed with significantly more hospitalizations in winter and spring and fewer in summer and fall. The cohort of manic-depressive patients was not different from the Indiana population generally with respect to season of birth.
对56名经过仔细诊断的躁郁症患者进行了评估，以探寻疾病发作、昼夜体温变化以及出生月份和季节之间的关系。关于昼夜体温变化，我们发现在每次疾病发作临近时，高温与低温之间的差异没有显著变化，但随着发作时间临近，高低温差异有减小的趋势。发作情况呈季节性分布，冬季和春季住院人数明显更多，夏季和秋季则较少。躁郁症患者群体在出生季节方面与印第安纳州总体人群没有差异。
