Nüssli R, Kind H P, Duc G
Eur J Pediatr. 1976 May 4;122(2):131-7. doi: 10.1007/BF00466271.
Premature twins both affected with generalized herpes simplex infection including CNS involvement were treated with 5-Iodo-2'-deoxyuridin (IDU). Therapy was started 6 days and 5 days, respectively, after appearance of the first symptoms. Nevertheless both babies died, twin A at the age of 24 and twin B at the age of 28 days. Herpes virus was cultured from all organs in twin A. The literature shows a decrease in mortality in children treated with IDU for herpes simplex encephalitis. The percentage of survivors with ultimate severe CNS damage, however, is very high and remains in treated or untreated patients the same. The institution of IDU therapy in neonates with manifest HSV encephalitis is therefore not unequivocally justified.
一对早产双胞胎均感染了包括中枢神经系统受累的全身性单纯疱疹病毒，接受了5-碘-2'-脱氧尿苷（IDU）治疗。分别在出现首例症状后的第6天和第5天开始治疗。然而，两个婴儿均死亡，双胞胎A在24天时死亡，双胞胎B在28天时死亡。在双胞胎A的所有器官中均培养出了疱疹病毒。文献表明，接受IDU治疗的单纯疱疹性脑炎患儿死亡率有所下降。然而，最终出现严重中枢神经系统损伤的幸存者比例非常高，且在接受治疗或未接受治疗的患者中保持不变。因此，对患有明显单纯疱疹病毒脑炎的新生儿采用IDU治疗并非毫无争议地合理。
