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基于抗原与合成聚合物免疫调节剂结构共轭的新一代疫苗的研发

[Development of new generation of vaccines based on structural conjugation of antigens and synthetic polymer immunomodulators].

作者信息

Khaitov R M

出版信息

Vopr Med Khim. 1997 Sep-Oct;43(5):390-401.

PMID:9446328
Abstract

The immunogenetic principle of creation of artificial antigens and vaccines possessing the abnormal immunogenecity and having capability to induce the high immune response in weakly reacting individuals have been suggested and proved by experiment. The vaccines of a new generation against the grippe pathogene, salmonellosis have been developed on the basis of this principle. In theory the methods of receiving allergovaccines for allergy disease therapy have been worked out and based.

摘要

具有异常免疫原性且能在反应较弱个体中诱导高免疫反应的人工抗原和疫苗的免疫遗传学原理已被提出并通过实验得到证实。基于这一原理,已研发出针对流感病原体、沙门氏菌病的新一代疫苗。理论上,已制定并建立了用于治疗过敏性疾病的变应原疫苗的制备方法。

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